Viral evolution and Immune responses
نویسندگان
چکیده
منابع مشابه
Autophagy Proteins in Viral Exocytosis and Anti-Viral Immune Responses
Abstract: Autophagy-related (Atg) gene-encoded proteins were originally described for their crucial role in macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes. Recently it has become clear that modules of this machinery can also be used to influence endo- and exocytosis. This mini review discusses how these alternative Atg functions support virus replicatio...
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We extend well-known mathematical models of viral infection to examine the response of cytotoxic T lymphocytes (CTL) to both conserved and variable viral epitopes. Because most viruses are subject to error-prone reproduction, CTL recognition may be faced with highly variable epitopes, while other CTL epitopes may remain conserved across viral strains. In this paper we examine the steady state c...
متن کاملViral escape and the failure of cellular immune responses.
Farci et al. (1) took an important step in understanding host-virus interactions in acute hepatitis C virus (HCV) infection, by demonstrating that increased viral diversity in the hypervariable region of the E2 envelope gene is associated with lack of control of infection. They suggested that, in those who fail to clear the virus, escape mutants arise in the hypervariable region, which leads to...
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Retinoic acid-inducible gene-I(RIG-I) is a cytoplasmic RNA helicase and a viral RNA sensor. RIG-I recognizes 5' triphosphate double-stranded RNA (dsRNA) and activates the IPS-1 adaptor molecule. The association of IPS-1 with RIG-I causes the formation of the prion-like structure of IPS-1. This structure is essential for activation of the signaling required for the induction of type I interferon...
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formatics pipeline to identify and classify all known viruses present in a metagenomic sample. Viral NGS reads are identified using a protein-based alignment method, DIAMOND, which is substantially faster than the standard BLAST method, and more reliable for viruses. These reads are automatically assembled into contigs using SPAdes, a de novo assembler. The contigs are then used to classify the...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology and Biochemical Technology
سال: 2019
ISSN: 2581-527X
DOI: 10.17352/jcmbt.000033